The other bioadhesive polymers had minimal impact on DcNa release. The tensile method to study bioadhesion found that bioadhesive properties decreased in the order of PVP > CBP > CMCTS > HPMC while the shear method PVP > CMCTS > CBP = HPMC. In both instances, HPMC showed poor bioadhesion with limited benefit in development of bioadhesive suppositories.
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